Indisulam
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CAS No. | 165668-41-7 | Cat. No. | BCP06110 |
Name | Indisulam | ||
Synonyms | E7070; E 7070; E-7070; ER35744; ER 35744; ER-35744; D04522; | ||
SMILES | |||
Chemical Name | |||
Formula | C14H12ClN3O4S2 | M. Wt | 385.85 |
Purity | 98% | Storage | Store at 4-8°C |
Description | Indisulam, also known as E7070, is a carbonic anhydrase inhbitor, is also a novel synthetic sulfonamide that targets the G1 phase of the cell cycle. The potential antitumor activity of Indisulam was discovered through optimization of the structure-activity relationships of a series of sulfonamide structures. Indisulam causes a blockade in the G1/S transition through inhibition of the activation of both cyclin-dependent kinase 2 and cyclin E. Preclinical studies with Indisulam showed activity in multiple tumor types, most prominently in colon and lung cancer. |
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