VER-246608
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1684386-71-7 | Cat. No. | BCP29722 |
| Name | VER-246608 | ||
| Synonyms | VER 246608; VER246608; | ||
| SMILES | CC1=CN=C(N=C1C2=CC=C(C=C2)N(CC3=CC=C(C=C3)CNC(=O)C(F)F)C(=O)C4=C(C=C(C=C4)O)O)Cl | ||
| Chemical Name | |||
| Formula | C28H23ClF2N4O4 | M. Wt | 552.96 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | VER-246608 is a novel pan-isoform ATP competitive inhibitor of pyruvate dehydrogenase kinase. VER-246608 disrupts Warburg metabolism and induces context-dependent cytostasis in cancer cells. Consistent with a PDK mediated MOA, VER-246608 increased pyruvate dehydrogenase complex (PDC) activity, oxygen consumption and attenuated glycolytic activity. VER-246608 was found to potentiate the activity of doxorubicin. | ||
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