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BAY-1436032 Chemical Structure

BAY-1436032

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP18989CAS No. ：1803274-65-8Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1803274-65-8 Cat. No. BCP18989
Name BAY-1436032
Synonyms BAY 1436032;BAY1436032;
SMILES
Chemical Name
Formula C26H30F3N3O3 M. Wt 489.53
Purity 98% Storage Store at 4-8°C
Description BAY-1436032 is a potent, selective and orally available inhibitor of mutant Isocitrate Dehydrogenase 1 (mIDH1). BAY 1436032 is a double-digit nanomolar and selective pan-inhibitor of the enzymatic activity of various IDH1-R132X mutants in vitro and displayed potent inhibition of 2-HG release (nanomolar range) in patient derived and engineered cell lines expressing different IDH1 mutants. In line with the proposed mode of action, a concentration-dependent lowering of 2-HG was observed in vitro accompanied by differentiation and maturation of mIDH1 tumor cells. Furthermore, BAY 1436032 showed a favourable selectivity profile against wtIDH1/2 and a large panel of off-targets in vitro.
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