SPHINX31 New
Data Sheet
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| CAS No. | 1818389-84-2 | Cat. No. | BCP30381 |
| Name | SPHINX31 | ||
| Synonyms | SPHINX 31;SPHINX-31; | ||
| SMILES | C1CN(CCN1CC2=CC=CC=N2)C3=C(C=C(C=C3)C(F)(F)F)NC(=O)C4=CC=C(O4)C5=CC=NC=C5 | ||
| Chemical Name | |||
| Formula | C27H24F3N5O2 | M. Wt | 507.51 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SPHINX31 is a potent inhibitor of serine/arginine-rich protein kinase 1 (SRPK1; IC50 = 5.9 nM).It is selective for SRPK1 over a panel of 50 kinases at a concentration of 1 μM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1), an SRPK1 substrate, in PC3 cells (EC50 = 360 nM) and increases expression of the anti-angiogenic VEGF-A165b splice variant in retinal pigment epithelial (RPE) cells. In vivo, SPHINX31 (2 μg per eye) inhibits blood vessel growth and macrophage infiltration in the eyes of a mouse model of choroidal neovascularization. | ||
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