KB-R7943 mesylate
Data Sheet
For research use only. Not for human use.
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| CAS No. | 182004-65-5 | Cat. No. | BCP02707 |
| Name | KB-R7943 mesylate | ||
| Synonyms | KB-R7943;KB-R 7943; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C17H21N3O6S2 | M. Wt | 427.5 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | KB-R7943 mesylate is a cell permeable, potent, selective NCKX inhibitor of the reverse mode of Na+/Ca2+ exchange in cells expressing NCX1.KB-R7943 reversibly inhibits inward and outward Na+/Ca2+ exchange in a dose-dependent manner, although it inhibits outward exchange more potently. Non-competitive with respect to Na+/Ca2+ and exhibits neuroprotection against glutamate excitotoxicity in rat cultured cerebellar granule neurons. KB-R7943 suppressed ventricular arrhythmias (tachycardia and fibrillation) associated with both ischemia and reperfusion almost completely in a rabbit ischemia-reperfusion model of cardiac injury. KB-R7943 is also a potent blocker of the transient receptor potential channels (TRPC) TRPC3, TRPC5 and TRPC6. KB-R7943 MESYLATE is an inhibitor of NCX1, NCX2, NCX3 and CCDC109. | ||
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