Carboxyamidotriazole Orotate New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 187739-60-2 | Cat. No. | BCP34906 |
| Name | Carboxyamidotriazole Orotate | ||
| Synonyms | L-651582 Orotate; CAI Orotate; L 651582; L-651582; L651582; NSC 609974; NSC609974; NSC-609974; | ||
| SMILES | C1=CC(=CC=C1C(=O)C2=C(C=C(C=C2Cl)CN3C(=C(N=N3)C(=O)N)N)Cl)Cl.C1=C(NC(=O)NC1=O)C(=O)O | ||
| Chemical Name | |||
| Formula | C23H16Cl3IN7O6 | M. Wt | 580.76 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Carboxyamidotriazole orotate is t he orotate salt form of carboxyamidotriazole (CAI), an orally bioavailable small molecule with potential antiangiogenic and antiproliferative activities. Carboxyamidotriazole binds to and inhibits non-voltage-operated calcium channels, blocking both Ca2+ influx into cells and Ca2+ release from intracellular stores, resulting in the disruption of calcium channel-mediated signal transduction. CAI inhibits PI3 activity and vascular endothelial growth factor (VEGF) signaling. This may inhibit endothelial proliferation, tumor cell growth, invasion and metastasis. | ||
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