CP 481715 New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP18399CAS No. ：212790-31-3Purity：98%

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CAS No.	212790-31-3	Cat. No.	BCP18399
Name	CP 481715
Synonyms	CP-481715;CP481715; CP-481,715; CP 481,715; CP481,71;
SMILES	CC(C)(CCC(CC(C(CC1=CC(=CC=C1)F)NC(=O)C2=NC3=CC=CC=C3N=C2)O)C(=O)N)O
Chemical Name
Formula	C26H31FN4O4	M. Wt	482.55
Purity	98%	Storage	Store at 4-8°C
Description	CP 481715 a potent and selective CCR1 antagonist with potential therapeutic implications for inflammatory diseases. CP-481,715 binds to human CCR1 with a Kd of 9.2 nm. and displaces 125I-labeled CCL3 from CCR1-transfected cells with an IC50 of 74 nm. CP-481,715 fully blocks the ability of CCL3 and CCL5 to stimulate receptor signaling (guanosine 5'-O-(thiotriphosphate) incorporation; IC50 = 210 nm), calcium mobilization (IC50 = 71 nm), monocyte chemotaxis (IC50 = 55 nm), and matrix metalloproteinase 9 release (IC50 = 54 nm). CP-481,715 retains activity in human whole blood, inhibiting CCL3-induced CD11b up-regulation and actin polymerization (IC50 = 165 and 57 nm, respectively) on monocytes. CP-481,715 inhibits cell infiltration and inflammatory responses in human CCR1 transgenic mice.