ZK824859 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2254001-81-3 | Cat. No. | BCP30356 |
| Name | ZK824859 | ||
| Synonyms | ZK-824859; ZK 824859；2271122-53-1; | ||
| SMILES | CC[C@@H](OC1=NC(OC2=CC(C3=CC=CC(CN)=C3)=CC(C)=C2)=C(F)C=C1F)C(O)=O | ||
| Chemical Name | |||
| Formula | C23H22F2N2O4 | M. Wt | 428.44 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | ZK824859 (ZK-824859) is a potent, selective urokinase plasminogen activator (uPA) inhibitor with IC50 of 79 nM (human uPA), displays little to no inhibitory activity against tPA and Plasmin (IC50>1 uM); ZK 824859 is 5 fold less potent and has lost selectivity in mouse: uPA IC50=410 nM; tPA IC50=910 nM; plasmin IC50=1600 nM; demonstrates efficacy in either acute or chronic mouse EAE models. | ||
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