HPK1-IN-22 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 2380300-79-6 | Cat. No. | BCP35846 |
| Name | HPK1-IN-22 | ||
| Synonyms | ZYF0033; | ||
| SMILES | CC(O)(C)C#CC1=CC=CC(COC2=CC(C3=CN=C(C4CCN(C)CC4)S3)=CN=C2N)=C1 | ||
| Chemical Name | |||
| Formula | C26H30N4O2S | M. Wt | 462.61 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | HPK1-IN-22 is a hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 less than 10 nM based on the phosphorylation inhibition of MBP protein. HPK1-IN-22 decreases the phosphorylation of SLP76 (serine 376). HPK1-IN-22 promotes anticancer immune responses. HPK1-IN-22 inhibits tumor growth and caused increases intratumoral infiltration of DCs, NK cells, and CD107a+CD8+ T cells but decreased infiltration of regulatory T cells, PD-1+CD8+ T cells, TIM-3+CD8+ T cells, and LAG3+CD8+ T cells in the 4T-1 syngeneic mouse model. | ||
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