Sufugolix New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP35686CAS No. ：308831-61-0Purity：98%

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CAS No.	308831-61-0	Cat. No.	BCP35686
Name	Sufugolix
Synonyms	TAK-013; TAK013; TAK 013;
SMILES	CN(CC1=CC=CC=C1)CC2=C(SC3=C2C(=O)N(C(=O)N3CC4=C(C=CC=C4F)F)C5=CC=CC=C5)C6=CC=C(C=C6)NC(=O)NOC
Chemical Name
Formula	C36H31F2N5O4S	M. Wt	667.73
Purity	98%	Storage	Store at 4-8°C
Description	Sufugolix is a non-peptide, orally-active, selective antagonist of the gonadotropin-releasing hormone receptor (GnRHR) (IC50 = 0.1 and 0.06 nM for affinity and in vitro inhibition, respectively). It was under development for the treatment of endometriosis and uterine leiomyoma and reached phase II clinical trials for both of these indications, but was subsequently discontinued. It seems to have been supplanted by relugolix (TAK-385), which is also under development by Takeda for the treatment of these conditions and has a more favorable drug profile (including reduced cytochrome P450 inhibition and improved in vivo GnRHR antagonistic activity) in comparison.