AR-C155858
Data Sheet
For research use only. Not for human use.
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| CAS No. | 496791-37-8 | Cat. No. | BCP13211 |
| Name | AR-C155858 | ||
| Synonyms | AR C155858;ARC155858; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C21H27N5O5S | M. Wt | 461.53 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Co-expression of exogenous embigin was without effect on either the expression of MCT1 or its inhibition by AR-C155858. In contrast, expression of active MCT2 at the plasma membrane of oocytes was significantly enhanced by co-expression of exogenous embigin. This additional transport activity was insensitive to inhibition by AR-C155858 unlike that by MCT2 expressed with endogenous basigin that was potently inhibited by AR-C155858. Derived values were 2.3+/-1.4 nM, 1.29+/-0.09 nmol per ml of packed cells and 12.2+/-1.1 s-1 respectively. When expressed in Xenopus laevis oocytes, MCT1 and MCT2 were potently inhibited by AR-C155858, whereas MCT4 was not. Inhibition of MCT1 was shown to be time-dependent, and the compound was also active when microinjected, suggesting that AR-C155858 probably enters the cell before binding to an intracellular site on MCT1 . | ||
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