Firibastat New
Data Sheet
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| CAS No. | 648927-86-0 | Cat. No. | BCP44770 |
| Name | Firibastat | ||
| Synonyms | RB-150; RB150;RB 150; QGC 001; QGC 001; QGC001; | ||
| SMILES | C(CS(=O)(=O)O)C(CSSCC(CCS(=O)(=O)O)N)N | ||
| Chemical Name | |||
| Formula | C8H20N2O6S4 | M. Wt | 368.51 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Firibastat, also known as QGC-001 and RB-150, is a glutamyl aminopeptidase antagonist potentially for the treatment of hypertension. Firibastat is an orally active prodrug of the specific and selective APA inhibitor, EC33. When given orally, RB150/firibastat crosses the gastrointestinal and blood-brain barriers, enters the brain, and generates two active molecules of EC33 which inhibit brain APA activity, blocking brain angiotensin III formation, and decrease blood pressure for several hours in hypertensive rats. | ||
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