RDEA594
Data Sheet
For research use only. Not for human use.
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| CAS No. | 878672-00-5 | Cat. No. | BCP06435 |
| Name | RDEA594 | ||
| Synonyms | RDEA-594;RDEA 594;Lesinurad; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C17H14BrN3O2S | M. Wt | 404.28 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | in vivo: In healthy subjects, the combination of 40 mg FBX with RDEA-594 reduced sUA by approximately 70% at the 200 mg and 400 mg RDEA-594 dose levels, respectively. In gout patients, FBX 40 mg and 80 mg alone reduced sUA by 35% and 47%, respectively. FBX 40 mg + RDEA-594 reduced sUA by 56% and 61% when combined with RDEA-594 400 mg or 600 mg. respectively, resulting in response rates of 100% for sUA <6 and <5 mg/dl and 64% <4 mg/dl. FBX 80 mg + RDEA-594 reduced sUA by 65% and 73% when combined with RDEA-594 400 mg or 600 mg respectively. Following single dosing of RDEA594, exposure of RDEA594 was significantly higher than those obtained from RDEA 806 dosing, >5X at 20 mg/kg in rats and >10X at 30 mg/kg in monkeys. | ||
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