PRI-724

  • Chemical Properties
CAS No. 1422253-38-0 Cat. No. BCP32677
Name PRI-724
Synonyms PRI724; PRI 724; C-82 prodrug; ICG-001 analog; ICG001 analog; ICG 001 analog;
Formula C33H35N6O7P M. Wt 658.65
  • Biological Activity
Description PRI-724 is a potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity. Wnt signaling pathway inhibitor PRI-724 specifically inhibits the recruiting of beta-catenin with its coactivator CBP (the binding protein of the cAMP response element-binding protein CREB); together with other transcription factors beta-catenin/CBP binds to WRE (Wnt-responsive element) and activates transcription of a wide range of target genes of Wnt/beta-catenin signaling.
Related Products 780757-88-2(ICG-001) 847591-62-2(ICG-001)
Pathways Wnt/Stem Cell 
Targets Wnt 

Structure

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