PRI-724
CAS No. | 1422253-38-0 | Cat. No. | BCP32677 |
Name | PRI-724 | ||
Synonyms | PRI724; PRI 724; C-82 prodrug; ICG-001 analog; ICG001 analog; ICG 001 analog; | ||
Formula | C33H35N6O7P | M. Wt | 658.65 |
Description | PRI-724 is a potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity. Wnt signaling pathway inhibitor PRI-724 specifically inhibits the recruiting of beta-catenin with its coactivator CBP (the binding protein of the cAMP response element-binding protein CREB); together with other transcription factors beta-catenin/CBP binds to WRE (Wnt-responsive element) and activates transcription of a wide range of target genes of Wnt/beta-catenin signaling. | ||
Related Products | 780757-88-2(ICG-001) 847591-62-2(ICG-001) | ||
Pathways | Wnt/Stem Cell | ||
Targets | Wnt |
Structure
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