PRI-724 New
Data Sheet
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| CAS No. | 1422253-38-0 | Cat. No. | BCP32677 |
| Related Products | 780757-88-2（ICG-001） 847591-62-2（ICG-001） | ||
| Name | PRI-724 | ||
| Synonyms | PRI724; PRI 724; C-82 prodrug; ICG-001 analog; ICG001 analog; ICG 001 analog; | ||
| SMILES | CC1C2N(C(C(=O)N1CC3=CC=CC4=C3N=CC=C4)CC5=CC=C(C=C5)OP(=O)(O)O)C(=O)CN(N2C(=O)NCC6=CC=CC=C6)C | ||
| Chemical Name | |||
| Formula | C33H35N6O7P | M. Wt | 658.65 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | PRI-724 is a potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity. Wnt signaling pathway inhibitor PRI-724 specifically inhibits the recruiting of beta-catenin with its coactivator CBP (the binding protein of the cAMP response element-binding protein CREB); together with other transcription factors beta-catenin/CBP binds to WRE (Wnt-responsive element) and activates transcription of a wide range of target genes of Wnt/beta-catenin signaling. | ||
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