ICG-001

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP13217CAS No. ：780757-88-2Purity：98%

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CAS No.	780757-88-2	Cat. No.	BCP13217
Related Products	1422253-38-0（PRI-724） 847591-62-2（ICG-001）
Name	ICG-001
Synonyms	ICG 001;ICG001;
SMILES
Chemical Name
Formula	C33H32N4O4	M. Wt	548.64
Purity	98%	Storage	Store at 4-8°C
Description	After treatment with 25μM of ICG-001 for 8 hours, SW480 cell reduces the steady-state levels of Survivin and Cyclin D1 RNA and protein, both of which can be up-regulated by β-catenin. ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces in vitro growth of colon carcinoma cells. ICG-001, can phenotypically rescue normal nerve growth factor (NGF) -induced neuronal differentiation and neurite outgrowth in the presenilin-1 mutant cells, emphasizing the importance of the TCF/β-catenin signaling pathway on neurite outgrowth and neuronal differentiation. A recent study demonstrates that 5μM ICG-001 inhibits leptin-induced EMT, invasion and tumorsphere formation in MCF7 cells.