阿法替尼双马来酸盐
| CAS号 | 850140-73-7 | 货号 | BCP08915 |
| 中文名 | 阿法替尼双马来酸盐 | ||
| 英文名 | BIBW2992 Dimaleate | ||
| 中文别名 | |||
| 英文别名 | BIBW 2992MA2; BIBW-2992; BIBW2992; BIBW 2992; Afatinib; Afatinib dimaleate; | ||
| 分子式 | C32H33ClFN5O11 | 分子量 | 718.08 |
| 生物活性 | Afatinib dimaleate is an orally bioavailable dual receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. EGFR/HER2 tyrosine kinase inhibitor BIBW 2992 irreversibly binds to and inhibits human epidermal growth factor receptors 1 and 2 (EGFR-1; HER2), which may result in the inhibition of tumor growth and angiogenesis. EGFR/HER2 are RTKs that belong to the EGFR superfamily; both play major roles in tumor cell proliferation and tumor vascularization and are overexpressed in many cancer cell types. Afatinib is approved in much of the world (including the United States, Canada, the United Kingdom and Australia) for the treatment of metastatic non-small cell lung carcinoma (NSCLC), developed by Boehringer Ingelheim. It acts as an angiokinase inhibitor. | ||
| 上下游产品 | 439081-18-2（阿法替尼） 850140-72-6（阿法替尼） | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase Jak/Stat Pathway | ||
| 靶 点 | EGFR HER2 | ||
结构式
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