阿法替尼双马来酸盐

参考资料仅供科学研究，不可用于个人用途。

货号：BCP08915CAS号：850140-73-7纯度：98%

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CAS号	850140-73-7	货号	BCP08915
关联产品	439081-18-2（阿法替尼） 850140-72-6（阿法替尼）
中文名	阿法替尼双马来酸盐
英文名	BIBW2992 Dimaleate
中文别名
英文别名	BIBW 2992MA2; BIBW-2992; BIBW2992; BIBW 2992; Afatinib; Afatinib dimaleate;
SMILES
化学名称
分子式	C32H33ClFN5O11	分子量	718.08
纯度	98%	配送	惯例下常温包邮
产品描述	Afatinib dimaleate is an orally bioavailable dual receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. EGFR/HER2 tyrosine kinase inhibitor BIBW 2992 irreversibly binds to and inhibits human epidermal growth factor receptors 1 and 2 (EGFR-1; HER2), which may result in the inhibition of tumor growth and angiogenesis. EGFR/HER2 are RTKs that belong to the EGFR superfamily; both play major roles in tumor cell proliferation and tumor vascularization and are overexpressed in many cancer cell types. Afatinib is approved in much of the world (including the United States, Canada, the United Kingdom and Australia) for the treatment of metastatic non-small cell lung carcinoma (NSCLC), developed by Boehringer Ingelheim. It acts as an angiokinase inhibitor.