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Afatinib(cis-trans isomerismtautomers) 结构式

阿法替尼(顺反异构体)

参考资料 仅供科学研究,不可用于个人用途。
货号 :BCP01779CAS号 :439081-18-2纯度:98%
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  • 基本信息与产品描述
CAS号 439081-18-2 货号 BCP01779
关联产品 850140-72-6(阿法替尼) 850140-73-7(阿法替尼双马来酸盐)
中文名 阿法替尼(顺反异构体)
英文名 Afatinib(cis-trans isomerismtautomers)
中文别名
英文别名 BIBW2992;Tovok;BIBW 2992;BIBW-2992;N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide;915958-11-1;
SMILES
化学名称
分子式 C24H25ClFN5O3 分子量 485.94
纯度 98% 配送 惯例下常温包邮
产品描述 BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2.
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