即时询价 ×
* 必填项
请填妥以下表格,您将在一分钟内得到邮件机器人给你的报价。
Inquiry Online
×
* Required Fields.
Please complete the form below and we will contact you shortly.
Bulk Inquiry
×
* Required Fields.
Please complete the form below and we will contact you shortly.
CAS号 | 850140-72-6 | 货号 | BCP04467 |
关联产品 | 439081-18-2(阿法替尼) 850140-73-7(阿法替尼双马来酸盐) | ||
中文名 | 阿法替尼 | ||
英文名 | Afatinib | ||
中文别名 | Gilotrif;Tovok; | ||
英文别名 | Gilotrif;Tovok;BIBW2992;BIBW-2992;BIBW 2992;(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide; | ||
SMILES | |||
化学名称 | |||
分子式 | C24H25ClFN5O3 | 分子量 | 485.94 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | BIBW2992 shows potent activity against both wild-type and mutant forms of EGFR and HER2. It is similar to Gefitinib in potency against L858R EGFR, but about 100-fold more active against the Gefitinib resistant L858R-T790M EGFR double mutant. BIBW2992 exhibits potent effects on both EGFR and HER2 phosphorylation in vivo. It compares favorably to reference compounds (such as Lapatinib et al.) in all cell types tested, such as human epidermoid carcinoma cell line A431 expressing wt EGFR, murine NIH-3T3 cells transfected with wt HER2, as well as breast cancer cell line BT-474 and gastric cancer cell line NCI-N87, which express endogenous HER2. |
相关产品推荐
查看更多 >Tags:Afatinib 供应商,Afatinib 购买,Afatinib 生产,Afatinib 批量,Afatinib 供应,Afatinib 订购,Afatinib 采购