CP 640186
| CAS号 | 591778-68-6 | 货号 | BCP09761 |
| 中文名 | CP 640186 | ||
| 英文名 | CP 640186 | ||
| 中文别名 | |||
| 英文别名 | CP-640186;CP640186; | ||
| 分子式 | C30H35N3O3 | 分子量 | 485.62 |
| 生物活性 | CP-640186 is a potent inhibitor of mammalian ACCs and can reduce body weight and improve insulin sensitivity in test animals. CP-640186 has recently been shown to be a potent inhibitor of isoforms of mammalian ACCs with IC50 values of about 55 nM. This is currently the only reported potent inhibitor of mammalian ACCs. In cell cultures as well as in animal models, CP-640186 can reduce tissue malonyl-CoA levels, inhibit fatty acid biosynthesis, and stimulate fatty acid oxidation. Most importantly, CP-640186 can reduce body fat mass and body weight, and improve insulin sensitivity, validating ACCs as targets for antiobesity and antidiabetes drugs. | ||
| 上下游产品 | 591778-70-0（CP-640186 hydrochloride） | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | ACC | ||
结构式
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