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| CAS号 | 591778-70-0 | 货号 | BCP18564 |
| 关联产品 | 591778-68-6（CP 640186） | ||
| 中文名 | CP-640186 hydrochloride | ||
| 英文名 | CP-640186 hydrochloride | ||
| 中文别名 | |||
| 英文别名 | CP 640186 hydrochloride;CP640186 hydrochloride; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C30H36ClN3O3 | 分子量 | 522.08 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | in vitro: CP-640186, also inhibited both isozymes with IC50s of ~55 nM but was 2–3 times more potent than CP-610431 in inhibiting HepG2 cell fatty acid and TG synthesis. CP-640186 also stimulated fatty acid oxidation in C2C12 cells (ACC2) and in rat epitrochlearis muscle strips with EC50s of 57 nM and 1.3 uM . in vivo: In rats, CP-640186 lowered hepatic, soleus muscle, quadriceps muscle, and cardiac muscle malonyl-CoA with ED50s of 55, 6, 15, and 8 mg/kg. Consequently, CP- 640186 inhibited fatty acid synthesis in rats, CD1 mice, and ob/ob mice with ED50s of 13, 11, and 4 mg/kg, and stimulated rat whole body fatty acid oxidation with an ED50 of ~30 mg/kg. | ||
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