Ixazomib

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02410CAS No. ：1072833-77-2Purity：98%

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CAS No.	1072833-77-2	Cat. No.	BCP02410
Name	Ixazomib
Synonyms	MLN 2238;MLN-2238;MLN2238;
SMILES
Chemical Name
Formula	C14H19BCl2N2O4	M. Wt	361.02
Purity	98%	Storage	Store at 4-8°C
Description	At higher concentrations, MLN2238 also inhibits the caspase-like (β1) and trypsin-like (β2) proteolytic sites with IC50 of 31nM and 3.5uM, respectively. MLN2238 inhibits Calu-6 cell with IC50 of 9.7 nM. MLN2238 is a selective, potent, and reversible inhibitor of the proteasome in tumor cells. MLN2238 shows time-dependent reversible proteasome inhibition. Both MLN2238 and Bortezomib shows time-dependent reversible proteasome inhibition; however, the proteasome dissociation half-life for MLN2238 is determined to be ～6-fold faster than that of Bortezomib (18 and 110 minutes, respectively). MLN2238 dissociates more rapidly from the proteasome than Bortezomib, consistent with faster recovery of proteasome activity observed in the Proteasome-Glo assay. MLN2238 has a greater overall tumor pharmacodynamic effect than Bortezomib as assessed by 20S inhibition. MLN2238 is the biologically active form of MLN9708.