NVP-BVU972

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP03600CAS No. ：1185763-69-2Purity：98%

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CAS No.	1185763-69-2	Cat. No.	BCP03600
Name	NVP-BVU972
Synonyms	BVU-972;BVU 972;BVU972;NVPBVU 972;NVP BVU 972;
SMILES
Chemical Name
Formula	C20H16N6	M. Wt	340.38
Purity	98%	Storage	Store at 4-8°C
Description	NVP-BVU972 potently inhibits MET kinase but displays low inhibition against other kinases including the most closely related kinase RON with IC50 values of more than 1000 nM. NVP-BVU972 also suppresses constitutive MET phosphorylation in GTL-16 cells or HGF-stimulated MET phosphorylation in A549 cells with IC50 values of 7.3 nM and 22 nM, respectively. NVP-BVU972 potently prevents the growth of the MET gene amplified cell lines GTL-16, MKN-45 and EBC-1 with IC50 values of 66 nM, 82 nM and 32 nM, respectively. In line with their high frequency in the NVP-BVU972 screen, Y1230 and D1228 mutations give rise to dramatic shifts in the measured IC50 values for NVP-BVU972 in BaF3 cell line. Resistance triggered by V1155L is more limited to NVP-BVU972. A dose-dependent reduction in TPR-MET phosphorylation when applying NVP-BVU972 to BaF3 cells expressing wild-type TPR-MET. Both Y1230H and D1228A mutations abrogated the effect of NVP-BVU972 but not AMG 458. However, F1200I and L1195V interferes