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Skepinone-L Chemical Structure

Skepinone-L

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP04105CAS No. ：1221485-83-1Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1221485-83-1 Cat. No. BCP04105
Name Skepinone-L
Synonyms Skepinone L;
SMILES
Chemical Name
Formula C24H21F2NO4 M. Wt 425.42
Purity 98% Storage Store at 4-8°C
Description Skepinone-L shows concentration-dependent inhibition of HSP27 (Ser82) phosphorylation through the p38 MAPK pathway with a cellular IC50 of approximately 25 nM, and also reduces concentrations of TNF-α, IL-1β and IL-10, regulated by p38 MAPK, with IC50 ranging from 30 to 50 nM .Skepinone-L (1 μM) abrogates the phosphorylation of platelet p38 MAPK substrate Hsp27 activated by stimulation with CRP, thrombin or thromboxane A2 analogue U-46619, and impairs platelet secretion and aggregation.
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LCMS H-NMR
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