Pexmetinib New

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP28410CAS No. ：945614-12-0Purity：98%

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CAS No.	945614-12-0	Cat. No.	BCP28410
Name	Pexmetinib
Synonyms	ARRY614; ARRY-614; ARRY 614;
SMILES	CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NCC3=C(C=CC(=C3)F)OC4=CC5=C(C=C4)N(N=C5)CCO
Chemical Name
Formula	C31H33FN6O3	M. Wt	556.63
Purity	98%	Storage	Store at 4-8°C
Description	Pexmetinib, also known as ARRY-614, is an orally bioavailable small-molecule inhibitor of p38 and Tie2 kinases with potential antineoplastic, anti-inflammatory and antiangiogenic activities. p38/Tie2 kinase inhibitor Arry-614 binds to and inhibits the activities of p38 and Tie2 kinases, which may inhibit the production of proinflammatory cytokines and may decrease tumor angiogenesis and tumor cell growth and survival. p38 is a MAP kinase that is often upregulated in cancer cells, playing a crucial part in the production of a variety of cytokines involved in inflammation and cellular proliferation such as tumor necrosis factor (TNF) and interleukin (IL)-1 and -6. Tie2 is an endothelial cell specific receptor that is activated by angiopoietins, growth factors required for angiogenesis.