BQ-123
Data Sheet
For research use only. Not for human use.
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| CAS No. | 136553-81-6 | Cat. No. | BCP29354 |
| Name | BQ-123 | ||
| Synonyms | BQ123; BQ 123；Cyclo(D-trp-D-asp-pro-D-val-leu)；Cyclo(D-alpha-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl); | ||
| SMILES | CC(C)CC1C(=O)NC(C(=O)NC(C(=O)N2CCCC2C(=O)NC(C(=O)N1)C(C)C)CC(=O)O)CC3=CNC4=CC=CC=C43 | ||
| Chemical Name | |||
| Formula | C31H42N6O7 | M. Wt | 610.7 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | BQ-123 is a elective ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively). BQ123 potentiates acetaminophen induced hypothermia and reduces infarction following focal cerebral ischemia in rats. BQ123 Stimulates Skeletal Muscle Antioxidant Defense via Nrf2 Activation in LPS-Treated Rats. BQ123 reduces pulmonary vascular resistance after surgical intervention for congenital heart disease. BQ123 protects against myocardial and endothelial reperfusion injury. | ||
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