Avosentan New
Data Sheet
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| CAS No. | 290815-26-8 | Cat. No. | BCP28417 |
| Name | Avosentan | ||
| Synonyms | SPP301; SPP301; SPP301; RO 67-0565; RO-67-0565; RO67-0565; R-639; | ||
| SMILES | CC1=CN=C(C=C1)S(=O)(=O)NC2=C(C(=NC(=N2)C3=CC=NC=C3)OC)OC4=CC=CC=C4OC | ||
| Chemical Name | |||
| Formula | C23H21N5O5S | M. Wt | 479.5 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Avosentan is an endothelin receptor antagonist. Avosentan ameliorates nephropathy and atherosclerosis in diabetic apolipoprotein E knockout mice. Avosentan is protective in hypertensive nephropathy at doses not causing fluid retention. Avosentan reduces albuminuria when added to standard treatment in people with type 2 diabetes and overt nephropathy but induces significant fluid overload and congestive heart failure. | ||
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