Ro 46-8443 New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 175556-12-4 | Cat. No. | BCP24181 |
| Name | Ro 46-8443 | ||
| Synonyms | RO46-8443; RO-46-8443; RO 468443; RO-468443; RO468443; RO 46,8443; RO-46,8443; RO46,8443; | ||
| SMILES | CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NC(=N2)C3=CC=C(C=C3)OC)OCC(CO)O)OC4=CC=CC=C4OC | ||
| Chemical Name | |||
| Formula | C31H35N3O8S | M. Wt | 609.69 |
| Purity | 98％ | Storage | Store at 4-8°C |
| Description | RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition. The observed parallel rightward shift of concentration-response curves with different antagonist concentrations is consistent with a competitive binding mode. Since R0 46-8443 selectively inhibits ETB receptor mediated responses, it is a valuable tool for clarifying the role of ETB receptors in pathology. | ||
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