GDC-0810
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1365888-06-7 | Cat. No. | BCP24812 |
| Name | GDC-0810 | ||
| Synonyms | GDC 0810; GDC-0810; ARN810; ARN 810; ARN-810; RG6046; RG-6046; RG 6046; Brilanestrant; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C26H20ClFN2O2 | M. Wt | 446.9 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Brilanestrant, also known as GDC-0810, ARN-810 and RG6046, an orally bioavailable Selective Estrogen Receptor Degrader (SERD) that demonstrates robust activity in tamoxifen-resistant breast cancer xenografts. GDC-0810 functions by binding to the estrogen receptor, inducing a conformational change resulting in the degradation of the receptor. GDC-0810 or ARN-810 demonstrates robust activity in models of tamoxifen-sensitive and tamoxifen-resistant breast cancer, and is currently in clinical trials in women with locally advanced or metastatic estrogen receptor-positive breast cancer. | ||
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