PD169316

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02234CAS No. ：152121-53-4Purity：98%

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CAS No.	152121-53-4	Cat. No.	BCP02234
Name	PD169316
Synonyms	PD-169316;PD 169316;
SMILES
Chemical Name
Formula	C20H13FN4O2	M. Wt	360.34
Purity	98%	Storage	Store at 4-8°C
Description	PD169316, a p38 MAPK inhibitor, abrogates signaling initiated by both TGFbeta and Activin A, but not bone morphogenetic protein (BMP) 4. Inhibition of TGFbeta signaling is dose dependent and results in reduced Smad2 and Smad3 phosphorylation, nuclear translocation, and up-regulation of the TGFbeta target gene Smad7. Reduced TGFbeta signaling is not due to abrogation of p38 MAPK activity, since blocking p38 MAPK activity with a dominant negative form of p38 MAPK has no effect on TGFbeta/Smad signaling. PD169316 at 5 μM or higher can block TGFβ signaling activity and thus caution must be used when attributing cellular activities exclusively to p38 MAPK signaling when these inhibitors are used experimentally. PD169316 significantly attenuated apoptosis in potassium-deprived cells in a dose dependent manner. PD169316 rescued the inhibitory effect of sphingosine on the formation of inositol phosphates by PGF(2alpha) or NaF in osteoblast-like MC3T3-E1 cells.