SB242235

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP05992CAS No. ：193746-75-7Purity：98%

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CAS No.	193746-75-7	Cat. No.	BCP05992
Name	SB242235
Synonyms	SB-242235;SB 242235;
SMILES
Chemical Name
Formula	C19H20FN5O	M. Wt	353.39
Purity	98%	Storage	Store at 4-8°C
Description	in vitro: SB 242235 inhibited intracellular p38 activity, human chondrocytes were treated with different doses of SB 242235 prior to stimulation with IL-1_ for 15 min. MAPKAP K2 was then isolated from these cells and assayed using HSP27 as a substrate. SB 242235 dose-dependently inhibited the activation of MAPKAP K2 with an IC50 of 1.0 uM . in vivo: SB-242235 demonstrates generally favourable pharmacokinetic properties in all species examined(including rat, dog and monkey). Systemic plasma clearance was high in rat, but in the non-rodent species SB-242235 demonstrated low to moderate clearance with plasma half-lives > 4h. Oral bioavailability in each preclinical species was high. In rat and monkey, SB-242235 demonstrated non-linear elimination kinetics that manifested as a decrease in clearance with increasing dose and apparent oral bioavailability > 100% at high oral doses .In the skin of SKH-1 hairless mice, SB242235, prior to UVB irradiation, blocked activation of the p38 MAPK casca