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TAK-715 Chemical Structure

TAK-715

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP01965CAS No. ：303162-79-0Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 303162-79-0 Cat. No. BCP01965
Name TAK-715
Synonyms TAK715;TAK 715;
SMILES
Chemical Name
Formula C24H21N3OS M. Wt 399.52
Purity 98% Storage Store at 4-8°C
Description TAK 715 inhibits LPS-stimulated release of TNF-alpha from THP-1 with IC50 of 48 nM. [1] TAK 715 (10 μM) inhibits Wnt-3a-induced hDvl2 phosphorylation and the hDvl2 shift in U2OS-EFC cells. [2] The amide NH of TAK 715 is hydrogen bonded to the main-chain carbonyl of Met109 of p38 alpha. TAK 715 binds relatively high in the ATP pocket, occupying the hydrophobic back pocket, the adenine region and the front pocket of p38 as well as extending to most of the length of the Gly-rich loop.
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