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losmapimod Chemical Structure

losmapimod

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP09909CAS No. ：585543-15-3Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 585543-15-3 Cat. No. BCP09909
Name losmapimod
Synonyms GW856553; GW-856553; GW 856553;GW856553X;GSK-AHAB;
SMILES CC1=C(C=C(C=C1F)C(=O)NC2CC2)C3=NC=C(C=C3)C(=O)NCC(C)(C)C
Chemical Name
Formula C22H26FN3O2 M. Wt 383.2
Purity 98% Storage Store at 4-8°C
Description Losmapimod is an orally bioavailable inhibitor of the alpha and beta isoforms of p38 mitogen-activated protein kinase (MAPK), with potential immunomodulating and anti-inflammatory activities. Upon oral administration, losmapimod inhibits the activity of p38alpha/beta MAPK, thereby preventing p38alpha/beta MAPK-mediated signaling. This may result in the inhibition of the production of proinflammatory cytokines. p38 MAPK, a serine/threonine protein kinase, plays an important role in regulating the transcription and translation of cytokines involved in inflammation including tumor necrosis factor alpha (TNF-alpha) and interleukin (IL)-1, IL-6 and IL-8.
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