PH-797804

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02266CAS No. ：586379-66-0Purity：98%

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CAS No.	586379-66-0	Cat. No.	BCP02266
Name	PH-797804
Synonyms	PH797804;PH 797804;
SMILES
Chemical Name
Formula	C22H19BrF2N2O3	M. Wt	477.3
Purity	98%	Storage	Store at 4-8°C
Description	PH-797804 blocks LPS-induced TNF-α production and p38 kinase activity in the human monocytic U937 cell line, with comparable IC50 of 5.9 nM and 1.1 nM. PH-797804 has no inhibitory effect on either the JNK pathway (c-Jun phosphorylation) or ERK pathway (ERK phosphorylation) in U937 cells at concentrations up to 1 μM. PH-797804 inhibits RANKL- and M-CSF-induced osteoclast formation in a concentration-dependent manner, with IC50 of 3 nM in primary rat bone marrow cells.IC50 values for PH-797804 against the following targets have been determined to be greater than 200 μM (unless specified): CDK2, ERK2, IKK1, IKK2, IKKi, MAPKAP2, MAPKAP3, MKK7 (>100 μM), MNK, MSK (>164 μM), PRAK, RSK2, and TBK1, which means the activity of PH-797804 is specific.