SB-297006
Data Sheet
For research use only. Not for human use.
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| CAS No. | 58816-69-6 | Cat. No. | BCP29726 |
| Name | SB-297006 | ||
| Synonyms | SB 297006；SB297006; | ||
| SMILES | CCOC(=O)C(CC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C2=CC=CC=C2 | ||
| Chemical Name | |||
| Formula | C18H18N2O5 | M. Wt | 342.35 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | SB-297006 is a potent and selective CCR3 antagonist (IC50 = 39 nM). Displays 250-fold selectivity for CCR3 over other chemokine receptors, including CXCR1, CXCR2, CCR1 and CCR7 (IC50 >27 μM). Inhibits calcium mobilization induced by MCP-4, eotaxin-2 and eotaxin in RBL-2H3 cells transfected with CCR3 (IC50 values are 80, 90 and 210 nM respectively). | ||
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