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ZK-756326 Chemical Structure

ZK-756326

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP20725CAS No. ：874911-96-3Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 874911-96-3 Cat. No. BCP20725
Name ZK-756326
Synonyms ZK 756326;ZK756326;
SMILES OCCOCCN1CCN(CC2=CC=CC(OC3=CC=CC=C3)=C2)CC1
Chemical Name
Formula C21H28N2O3 M. Wt 356.47
Purity 98% Storage Store at 4-8°C
Description ZK 756326 is a selective, non-peptide CKR-8 (CCR8 chemokine receptor) agonist (IC50 values are 1.8 and 2.6μM for human and mouse receptors respectively). Induces chemotaxis and inhibits Env-mediated (HIV) cell-cell fusion. ZK 756326 displays no activity at CCR4, CXCR3, CXCR4 and CCR5 and shows > 28-fold selectivity over 26 other GPCRs.Selective, non-peptide CCR8 chemokine receptor agonist (IC50 values are 1.8 and 2.6 μM for human and mouse receptors respectively). Displays no activity at CCR4, CXCR3, CXCR4 and CCR5 and shows > 28-fold selectivity over 26 other GPCRs (less selective at α2A and 5-HT receptors). Induces chemotaxis and inhibits Env-mediated (HIV) cell-cell fusion.
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