TAK-220 Hydrochloride New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 674782-27-5 | Cat. No. | BCP37346 |
| Name | TAK-220 Hydrochloride | ||
| Synonyms | TAK220 Hydrochloride;TAK220 HCl; | ||
| SMILES | CC1=C(C=C(C=C1)N(CCCN2CCC(CC2)CC3=CC=C(C=C3)C(=O)N)C(=O)C4CCN(CC4)C(=O)C)Cl.Cl | ||
| Chemical Name | |||
| Formula | C31H42Cl2N4O3 | M. Wt | 589.6 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | TAK-220 is a selective and orally bioavailable CCR5 antagonist, with IC50s of 3.5 nM and 1.4 nM for inhibition on the binding of RANTES and MIP-1α to CCR5, respectively, but shows no effect on the binding to CCR1, CCR2b, CCR3, CCR4, or CCR7; TAK-220 also selectively inhibits HIV-1, with EC50s of 1.2 nM (HIV-1 KK), 0.72 nM (HIV-1 CTV), 1.7 nM (HIV-1 HKW), 1.7 nM (HIV-1 HNK), 0.93 nM (HIV-1 HTN), and 0.55 nM (HIV-1 HHA), and EC90s of 12 nM (HIV-1 KK), 5 nM (HIV-1 CTV), 12 nM (HIV-1 HKW), 28 nM (HIV-1 HNK), 15 nM (HIV-1 HTN), and 4 nM (HIV-1 HHA) in PBMCs. | ||
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