4-Hydroxytamoxifen

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP23058CAS No. ：68047-06-3Purity：98%

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Chemical Properties&Biological Activity

CAS No.	68047-06-3	Cat. No.	BCP23058
Name	4-Hydroxytamoxifen
Synonyms	(Z)-4-Hydroxytamoxifen; trans-4-Hydroxytamoxifen; ICI 79280; ICI79280; ICI-79280;
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Chemical Name
Formula	C26H29NO2	M. Wt	387.51
Purity	98%	Storage	Store at 4-8°C
Description	4-Hydroxytamoxifen, an active metabolite of tamoxifen, is a selective estrogen receptor antagonist, with an IC50 of 3.3 nM for the [3H]oestradiol binding to oestrogen receptor, widely used to treat breast cancer; also increases CRISPR/Cas9-mediated editing frequency.trans-4-Hydroxytamoxifen is a SERM and active metabolite of tamoxifen. The Z isomer is more active than the E isomer. It induces autophagy, vacuole formation and KRAS degredation in cancer cells and decreases contractility in myocytes.

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4-Hydroxytamoxifen

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