SKF-86002

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP14402CAS No. ：72873-74-6Purity：98%

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CAS No.	72873-74-6	Cat. No.	BCP14402
Name	SKF-86002
Synonyms	SKF 86002;SKF86002;
SMILES
Chemical Name
Formula	C16H12FN3S	M. Wt	297.36
Purity	98%	Storage	Store at 4-8°C
Description	SKF-86002 inhibited prostaglandin H2 (PGH2) synthase activity (IC50 120 microM) as well as prostanoid production by rat basophilic leukemia (RBL-1) cells (IC50 70 microM) and its sonicate (IC50 100 microM) and human monocytes (IC50 1 microM). In addition, SK&F 86002 inhibited the generation of dihydroxyeicosatetraenoic acid (diHETE) and 5-hydroxyeicosatetraenoic acid (5-HETE) by a high speed supernatant fraction of RBL-1 cells (IC50 10 microM) . differentiation of HL-60 cells toward the neutrophil phenotype resulted in a loss in c-Jun NH2-terminal kinase activation with concomitant acquisition of formylmethionylleucylphenylalanine-stimulatable and stress-inducible p38 MAPK activity as well as apoptosis blockade by SKF-86002 . SKF-86002 blocked superoxide anion production in response to FMLP and reduced adhesion and chemotaxis in response to PAF or FMLP.