CEP-18770

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP05719CAS No. ：847499-27-8Purity：98%

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CAS No.	847499-27-8	Cat. No.	BCP05719
Name	CEP-18770
Synonyms	Delanzomib;CEP18770;CEP 18770;CIP 18770;CT 47098;NPH 007098;
SMILES
Chemical Name
Formula	C21H28BN3O5	M. Wt	413.28
Purity	98%	Storage	Store at 4-8°C
Description	CEP-18770 demonstrates marginal prevention of the tryptic and peptidyl gultamyl activities of the protesome. The IC50 values of CEP-18770 are similar to those of bortezomib, with the chymotryptic and caspase-like activities being inhibited at low-nanomolar concentrations.CEP-18770 inhibits A2780 ovarian cancer cells, PC3 prostate cancer, H460, LoVo colon cancer, RPMI8226 multiple myeloma cancer and HS-Sultan anaplastic non-Hodgkin lymphoma with IC50 values of 13.7, 22.2, 34.2 11.3, 5.6 and 8.2 nM, respectively.CEP-18770 blocks the ubiquitin-proteasome pathway in several MM and in the chronic myelogenous leukemia cell line, K562. CEP-18770 causes an accumulation of ubiquitinated proteins over 4 to 8 hours with a profile similar to that observed after bortezomib treatment.IκBα degradation is completely blocked by pretreatment with CEP-18770. CEP-18770 significantly inhibits high levels of NF-κB activity in both RPMI-8226 and U266 cells. The time- and concentration-dependent suppression o