LY2228820 2MsOH
Data Sheet
For research use only. Not for human use.
Get Quotation Now* Required Fields.
Please complete the form below and you will get the price list in 1 minute.
* Required Fields.
Please complete the form below and we will contact you shortly.
* Required Fields.
Please complete the form below and we will contact you shortly.
| CAS No. | 862507-23-1 | Cat. No. | BCP02295 |
| Name | LY2228820 2MsOH | ||
| Synonyms | LY2228820 diMesylate; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C24H29FN6.2CH4O3S | M. Wt | 612.74 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | LY2228820 inhibits p38α, as well as the level of phosphoMAPKAPK-2 (pMK2) in RAW 264.7 cells, with IC50 values of 7 nM and 34.3 nM, respectively. Furthermore, LY2228820 inhibits lipopolysaccharide (LPS)-induced TNFα formation in murine peritoneal macrophages, with IC50 of 5.2 nM.In multiple myeloma (MM) cells, including INA6, RPMI-8226, U266, and RPMI-Dox40, LY2228820 (200 nM–800 nM) significantly blocks p38MAPK signaling, as revealed by its inhibition on phosphorylation of HSP27, a downstream target of p38MAPK, without affecting the expression level of HSP27. LY2228820 (200 nM–400 nM) enhances bortezomib-induced cytotoxicity and apoptosis, but LY2228820 alone doesn't inhibit the growth of MM.1S cells. LY2228820 (200 nM–800 nM) also inhibits secretion of IL-6 and MIP-1α in long-term BM stromal cells (LT-BMSCs), BM mononuclear cells (BMMNCs), peripheral blood (PB) CD138+, CD138? or PB CD14+ cells. LY2228820 (400 nM–800 nM) also blocks osteoclastogenesis from CD14+ cells. | ||
Recommend Products
More >
-
(S)-(-)-PH-797804
Cat. No.：BCP49370
No.：1358027-80-1
Product Details -
Exarafenib
Cat. No.：BCP49200
No.：2639957-39-2
Product Details -
p38-α MAPK inhibitor 1
Cat. No.：BCP48493
No.：443913-15-3
Product Details -
-
SB-747651A
Cat. No.：BCP46274
No.：607372-46-3
Product Details -
SB-747651A dihydrochloride
Cat. No.：BCP46273
No.：1781882-72-1
Product Details -
PF-05381941
Cat. No.：BCP45842
No.：1474022-02-0
Product Details -
-
-
MW-150 dihydrochloride dihydrate
Cat. No.：BCP30837
No.：1661020-92-3
Product Details -
ITX-5061 HCl
Cat. No.：BCP30784
No.：1252679-52-9
Product Details -
-
-
SB 203580 hydrochloride
Cat. No.：BCP29070
No.：869185-85-3
Product Details -
FR 167653 sulfate
Cat. No.：BCP25927
No.：158876-66-5
Product Details -
-
Pexmetinib
Cat. No.：BCP28410
No.：945614-12-0
Product Details -
-
-
SB202190 HCl
Cat. No.：BCP21617
No.：350228-36-3
Product Details
Tags:LY2228820 2MsOH supplier,LY2228820 2MsOH purchase,LY2228820 2MsOH manufacturer,LY2228820 2MsOH distributor,LY2228820 2MsOH cost,LY2228820 2MsOH buy,LY2228820 2MsOH for sale