Carfilzomib New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 868540-17-4 | Cat. No. | BCP02588 |
| Name | Carfilzomib | ||
| Synonyms | PR 171;PR171;PR-171; | ||
| SMILES | CC(C)CC(C(=O)C1(CO1)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(C)C)NC(=O)C(CCC3=CC=CC=C3)NC(=O)CN4CCOCC4 | ||
| Chemical Name | |||
| Formula | C40H57N5O7 | M. Wt | 719.91 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Carfilzomib inhibits proliferation in a variety of cell lines and patient-derived neoplastic cells, including multiple myeloma, and induced intrinsic and extrinsic apoptotic signaling pathways and activation of c-Jun-N-terminal kinase (JNK). Carfilzomib reveals enhanced anti-MM activity compared with bortezomib, overcome resistance to bortezomib and other agents, and acts synergistically with dexamethasone (Dex). Carfilzomib shoes preferential in vitro inhibitory potency against the ChT-L activity in the β5 subunit, with over 80% inhibition at doses of 10 nM. | ||
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