Tivantinib

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP02529CAS No. ：905854-02-6Purity：98%

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CAS No.	905854-02-6	Cat. No.	BCP02529
Name	Tivantinib
Synonyms	ARQ197;ARQ-197;ARQ 197;1000873-98-2;
SMILES
Chemical Name
Formula	C23H19N3O2	M. Wt	369.42
Purity	98%	Storage	Store at 4-8°C
Description	ARQ-197 has been shown to prevent HGF/c-met induced cellular responses in vitro. ARQ-197 possesses antitumor activity; inhibiting proliferation of A549, DBTRG and NCI-H441 cells with IC50 of 0.38, 0.45, 0.29 μM. Treatment with ARQ-197 results in a decrease in phosphorylation of the MAPK signaling cascade and prevention of invasion and migration. In addition, ectopic expression of c-Met in NCI-H661, a cell line having no endogenous expression of c-Met, causes it to acquire an invasive phenotype that is also suppressed by ARQ-197. Although the addition of increasing concentrations of ARQ-197 does not significantly affect the Km of ATP, exposure of c-Met to 0.5 μM ARQ-197 decreased the Vmax of c-Met by approximately 3-fold. The ability of ARQ-197 to decrease the Vmax without affecting the Km of ATP confirmed that ARQ-197 inhibits c-Met through a non–ATP-competitive mechanism and may therefore account for its high degree of kinase selectivity. ARQ-197 prevents human recombinant c-Met with