ARRY-380 analog
Data Sheet
For research use only. Not for human use.
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| CAS No. | 937265-83-3 | Cat. No. | BCP02833 |
| Name | ARRY-380 analog | ||
| Synonyms | HER2-Inhibitor-1;ARRY-380; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C29H27N7O4S | M. Wt | 569.63 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | ARRY-380 analog is an analog of ARRY-380. ARRY-380 is also know as Tucatinib, also known as Irbinitinib, and ONT-380, is a n orally bioavailable inhibitor of the human epidermal growth factor receptor tyrosine kinase ErbB-2 (also called HER2) with potential antineoplastic activity. ErbB-2 inhibitor ARRY-380 selectively binds to and inhibits the phosphorylation of ErbB-2, which may prevent the activation of ErbB-2 signal transduction pathways, resulting in growth inhibition and death of ErbB-2-expressing tumor cells. ErbB-2 is overexpressed in a variety of cancers and plays an important role in cellular proliferation and differentiation. | ||
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