SB743921
Data Sheet
For research use only. Not for human use.
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| CAS No. | 940929-33-9 | Cat. No. | BCP02471 |
| Name | SB743921 | ||
| Synonyms | SB-743921;SB 743921; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C31H33N2O3.HCl | M. Wt | 553.53 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | The Ki of SB 743921 for human and mouse KSP is 0.1 nM and 0.12 nM, respectively, while the Ki of SB 743921 for other kinesins including MKLP1, Kin2 is more than 70 μM. SB 743921 blocks assembly of a functional mitotic spindle, thereby causing cell cycle arrest in mitosis and subsequent cell death. SB-743921 has improved potency over ispinesib in both biochemical and cellular assays. | ||
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