JNJ-38877605

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP01812CAS No. ：943540-75-8Purity：98%

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Chemical Properties&Biological Activity

CAS No.	943540-75-8	Cat. No.	BCP01812
Name	JNJ-38877605
Synonyms	JNJ38877605;JNJ 38877605;
SMILES
Chemical Name
Formula	C19H13F2N7	M. Wt	377.35
Purity	98%	Storage	Store at 4-8°C
Description	JNJ-38877605 shows more than 600-fold selectivity for c-Met compared with more than 200 other diverse tyrosine and serine-threonine kinases and also potently inhibits HGF-stimulated and constitutively activated c-Met phosphorylation in vitro. In EBC1, GTL16, NCI-H1993, and MKN45 cells, JNJ-38877605 (500 nM) leads to a significant reduction of phosphorylation of Met and RON, another key player in invasive growth. A recent study shows that JNJ-38877605 is involved in modulating secretion of IL-8, GROa, uPAR and IL-6 in GTL16 cells.

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JNJ-38877605

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