Telotristat
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1033805-28-5 | Cat. No. | BCP13199 |
| Name | Telotristat | ||
| Synonyms | LP778902;LP 778902;LP-778902; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C25H22ClF3N6O3 | M. Wt | 546.93 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | LX1606 (LX 1606, LX-1606) is useful for Neurological Diseas . LX1606 were given orally to mice. LX1606 reduced 5-HT significantly in the gut and blood but not in the brain. oral LX1032 reduced the severity of TNBS-induced colitis; the expression of 24% of 84 genes encoding inflammation-related cytokines and chemokines was lowered at least fourfold and the reduced expression of 17% was statistically significant . Treatment with LX1606 showed a strong positive effect in ameliorating TNBS-induced IBD in mice as assessed by various parameters of disease development. These preclinical data demonstrate that inhibition of TPH activity by LX1606 may provide a new approach for the treatment of IBD and its serotonin-mediated symptoms. | ||
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