Calicheamicin New
Data Sheet
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| CAS No. | 108212-75-5 | Cat. No. | BCP30641 |
| Name | Calicheamicin | ||
| Synonyms | Calicheamicin γ1;Calicheamicin gamma(1,I); Calichemicin gamma1; Calicheamicin gamma(1)I;Calicheamicin γ1I; | ||
| SMILES | CCNC1COC(CC1OC)OC2C(C(C(OC2OC3C#CC=CC#CC4(CC(=O)C(=C3C4=CCSSSC)NC(=O)OC)O)C)NOC5CC(C(C(O5)C)SC(=O)C6=C(C(=C(C(=C6OC)OC)OC7C(C(C(C(O7)C)O)OC)O)I)C)O)O | ||
| Chemical Name | |||
| Formula | C55H74IN3O21S4 | M. Wt | 1368.35 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Calicheamicin is an potent enediyne antitumor antibiotics derived from the bacterium Micromonospora echinospora. Calicheamicin targets DNA and cause strand scission. Calicheamicin binds with DNA in the minor groove, wherein it then undergos a reaction analogous to the Bergman cyclization to generate a diradical species. This diradical, 1,4-didehydrobenzene, then abstracts hydrogen atoms from the deoxyribose (sugar) backbone of DNA, which ultimately leads to strand scission. The specificity of binding of calicheamicin to the minor groove of DNA is due to the aryltetrasaccharide group of the molecule. | ||
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