Clopidogrel hydrogen sulfate New
Data Sheet
For research use only. Not for human use.
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| CAS No. | 120202-66-6 | Cat. No. | BCP06463 |
| Name | Clopidogrel hydrogen sulfate | ||
| Synonyms | Clopidogrel sulfate;(S)-(+)-Clopidogrel bisulfate; (S)-(+)-Clopidogrel hydrogen sulfate; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C16H18ClNO6S2 | M. Wt | 419.89 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Clopidogrel is an effective antiplatelet agent useful for the treatment of ischemic cerebrovascular, cardiac, and peripheral arterial disease. Clopidogrel abolishes the inhibitory P2Y(AC) receptor-mediated ADP effects on prostaglandin E(1)-stimulated, cAMP-dependent phosphorylation of VASP without affecting epinephrine, thrombin, and thromboxane signaling. VASP phosphorylation is known to be closely correlated with the inhibition of platelet and fibrinogen receptor (glycoprotein IIb/IIIa) activation. Therefore, inhibition of the platelet P2Y(AC) ADP receptor and its intracellular signaling, including decreased VASP phosphorylation, is suggested as a molecular mechanism of clopidogrel action. Clopidogrel ingestion reduced the thrombus volume significantly (p < 0.05) at 100 and 2600 s-1 (39 and 51% respectively). clopidogrel reduced significantly the fibrinopeptide A plasma levels and the fibrin deposition at shear rates below 650 s-1 . | ||
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